PET ADVANCES - Projected Developments and Applications of PET
The design of the first prototype EXPLORER Total Body PET scanner, in collaboration with United Imaging Healthcare has been completed in 2018 and the first humans imaged in the Fall of 2018.
PET Scanning in 2017
Total Body PET 2018
For details of the EXPLORER project and areas of application of this advanced PET scanner technology read:
EXPLORER consortium website. https://explorer.ucdavis.edu/.
Cherry SR, Badawi RD, Karp JS, Moses WW, Price P, Jones T. Total-body imaging:
transforming the role of positron emission tomography. Sci Transl Med. 2017;9: eaaf6169.
Simon R. Cherry, Terry Jones, Joel S. Karp, Jinyi Qi, William W. Moses, Ramsey D. Badawi Total Body PET: Maximizing sensitivity to create new opportunities for clinical research and patient care J Nuc Med; 2018; 59:3–12
The first human studies with the u EXPLORER were undertaken at United Imaging Healthcare Shanghai in the Fall of 2018. These included both static and dynamic 18FDG imaging:
Badawi, R. D., H. C. Shi, P. C. Hu, S. G. Chen, T. Y. Xu, P. M. Price, Y. Ding, B. A. Spencer, L. Nardo, W. P. Liu, J. Bao, T. Jones, H. D. Li and S. R. Cherry (2019). "First Human Imaging Studies with the EXPLORER Total-Body PET Scanner." Journal of Nuclear Medicine 60(3): 299-303.
FDA approval for human applications was received in 2018
Zhang X, Xie Z, Berg E, Judenhofer MS, Liu W, Xu T, Ding Y, Lv Y, Dong Y, Deng Z, Tang S, Shi H, Hu P, Chen S, Bao J, Li H, Zhou J, Wang G, Cherry SR, Badawi RD and Qi J. Total-Body Dynamic Reconstruction and Parametric Imaging on the uEXPLORER. J Nucl Med 2020; 61: 285-291
Zhang X, Cherry SR, Xie Z, Shi H, Badawi RD, Qi J, “Subsecond total-body imaging using ultrasensitive positron emission tomography”. Proceedings of the National Academy of Sciences of the United States of America, 117(5): 2265-2267 (2020).
Spencer B A, Berg E, Schmall J P, Omidvari N, Leung N E K, YAbdelhafez Y G, Tang S, Deng Z, Dong Y, Lv Y, Bao J, Liu W, Li H, Jones T, Badawi R. D and S. R. Cherry S. R. (2020). "Performance evaluation of the uEXPLORER Total-body PET/CT scanner based on NEMA NU 2-2018 with additional tests to characterize long axial field-of-view PET scanners." J Nucl Med 2021; 62:861–870.
Leung E, Berg E, Omidvari N, Spencer B, Li E, Abdelhafez Y; Schmall J, Liu W, He L, Tang S, Liu Y, Dong Yun, Jones T, Cherry S, Badawi R Quantitative accuracy in total-body imaging using the uEXPLORER PET/CT scanner" by. Article reference: PMB-112348.R1 2021
Feng T, Zhao Y, Shi H, Li H, Zhang X, Wang G, Badawi RD, Price PM, Jones T and Cherry SR. Total-Body Quantitative Parametric Imaging of Early Kinetics of FDG J Nucl Med 2021; 62:738 –744
Wang G, Nardo L, Parikh M, Abdelhafez Y G, Li E, Spencer B A, Qi J, Jones T, Cherry S R, Badawi R D. Total-Body PET Multiparametric Imaging of Cancer Using a Voxel-wise Strategy of Compartmental Modelling Journal of Nuclear Medicine -under review 2021.
A second u EXPLORER was established at the Zhongshan Hospital in Shanghai in 2019. As of 0ctober 2021 there are 6 u EXPLORER scanners in China.